The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in water and a bit soluble in Liquor. The molecular fat is 406.37. Its molecular method is C18H21NO3•H3PO4 • ½ H2O, and it has the subsequent chemical framework.
Never make use of a home teaspoon to measure your drugs. Chances are you'll accidentally just take an excessive amount of. You may inquire your pharmacist with the measuring device you should use and the way to measure the right dose.
Antiemetics are usually not recommended for therapy of uncomplicated vomiting in pediatric clients, as well as their use must be restricted to prolonged vomiting of recognized etiology. The extrapyramidal signs or symptoms which could manifest secondary to Promethazine HCl Oral Remedy administration can be confused While using the CNS signs of undiagnosed Major ailment, e.g., encephalopathy or Reye's syndrome. The usage of Promethazine HCl Oral Answer ought to be prevented in pediatric patients whose signals and indicators could counsel Reye's syndrome or other hepatic health conditions.
The subsequent major adverse reactions are explained, or explained in bigger detail, in other sections:
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients under six several years of age. Concomitant administration of promethazine merchandise with other respiratory depressants has an Affiliation with respiratory despair, and sometimes Dying, in pediatric patients.
Codeine may well increase the neuromuscular blocking action of skeletal muscle mass relaxants and create an elevated degree of respiratory depression.
If the client develops these symptoms or symptoms, elevate the dose to your previous amount and taper a lot more slowly, possibly by expanding the interval amongst decreases, decreasing the level of improve in dose, or both equally.
Phenothiazines are connected with dystonic reactions, specially in pediatric patients that have an acute illness connected with dehydration. Paradoxical reactions, which includes dystonia, torticollis, tongue protrusion, hyperexcitability, and irregular movements have already been described in patients adhering to an individual administration of promethazine. Discontinue Promethazine HCl and Codeine Phosphate Oral Solution if a paradoxical reaction happens.
Treatment method of Overdose Procedure of overdosage is driven by the overall scientific presentation, and includes discontinuation of Promethazine HCl and Codeine Phosphate Oral Alternative together with establishment website of appropriate therapy. Give Key focus to the reestablishment of satisfactory respiratory exchange by provision of a patent and protected airway and also the institution of assisted or managed ventilation.
Avoidance and Charge of nausea and vomiting affiliated with sure types of anesthesia and operation.
This may take place even if you acquire Promethazine Hydrochloride and Codeine Phosphate Oral Alternative accurately as prescribed by your Health care provider. Your danger of habit, abuse, and misuse is elevated when you or perhaps a relative incorporates a historical past of drug or Liquor abuse or dependancy, or mental health issues.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients a lot less than 6 several years of age, mainly because The mixture could bring about fatal respiratory melancholy in this age inhabitants (see WARNINGS Box Warning and Use in Pediatric Sufferers).
Observational experiments have shown that concomitant use of opioid analgesics and benzodiazepines increases the threat of drug-related mortality as compared to utilization of opioids by itself.
Physical dependence, the issue wherein ongoing administration of the drug is needed to stop the looks of the withdrawal syndrome, assumes clinically sizeable proportions only following many months of ongoing oral opioid use, Even though some delicate degree of Bodily dependence could build just after a couple of days of opioid therapy.